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Worksteam Leader |
Simon Dolan, GSK |
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Work Stream Objectives |
The aim of this proposal is to start to look closely at the technical issues and economics of scale up in flow, baselined against the batch equivalent. |
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Strands summary |
Explore the factors affecting conversion rates in flow for selected substrates of industrial relevance (one from each of GSK, AZ) and a more generic set of amine compounds to gauge the breadth of utility. Factors are: maintaining amine donor concentrations throughout the column, alternative amine donors to IPM, impact of residual water content and nature of solvent composition
Assess the impact of catalyst performance on the above by using different biocatalysts and immobilization strategies |
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Determine the stability of the catalysts and performance with time in the reaction media and impact on reaction rate. Examine use of different flow systems – Plug Flow, CSTR, Multi-stage (e.g. Coflore) advantages/disadvantages Investigation of isolation/purification process to enable a complete process for delivering chiral amines. Includes the removal of acetone to drive equilibrium (e.g. via wipe film evaporation) |
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Home » Research » Project Structure » Workstream (App) “F” – Enzymes in Flow/ Continuous Flow Synthesis of Chiral Amines
